pertussis toxin उदाहरण वाक्य
उदाहरण वाक्य
- None of the patients appeared to have experienced any unusual vaccine reactions despite the fact that the pediatric formulation contains greater amounts of the detoxified pertussis toxin and diphtheria toxoid.
- Other scientists have developed techniques for using melanophores as biosensors, and for rapid disease detection ( based on the discovery that pertussis toxin blocks pigment aggregation in fish melanophores ).
- "B . bronchiseptica " does not express pertussis toxin, which is one of the characteristic virulence factors of " B . pertussis ", but it has the genes to do so, highlighting the close evolutionary relationship between the two species .,
- After their B subunit binds to receptors on the cell surface, the toxin is enveloped by the cell and transported inside either through The mechanism pathways for the four AB5 toxins : cholera toxin, pertussis toxin, shiga toxin, and subtilase cytotoxin.
- The addition of anti-CD40 causes the B cells to resemble those found in the GC . Pertussis toxin is known to inhbibit the action of G proteins and B cells treated with the toxin were observed to migrate poorly in response to FDC-SP.
- Briefly, they cloned the pertussis toxin, mapped the antigenic epitopes using antibodies from individuals, who had the disease and or were vaccinated with the old whole-cell vaccine, and attached these antigenic peptides onto the diphtheria toxin as a carrier and adjuvant in one.
- Serology may be used for adults and adolescents who have already been infected for several weeks to determine whether antibody against pertussis toxin or another virulence factor of " B . pertussis " is present at high levels in the blood of the person.
- The pertussis toxin ( also an AB 5 protein ) produced by " Bordetella pertussis " acts in a similar manner with the exception that it ADP-ribosylates the G? " i " subunit, rendering it inactive and unable to inhibit adenylyl cyclase production of cAMP ( leading to constitutive production ).
- The toxin, known as pertussis toxin ( or PTx ), inhibits G protein coupling that regulates an adenylate cyclase-mediated conversion of ATP to cyclic AMP . The end result is phagocytes convert too much ATP to cyclic AMP, which can cause disturbances in cellular signaling mechanisms, and prevent phagocytes from correctly responding to an infection.