lagging strand उदाहरण वाक्य
उदाहरण वाक्य
- Furthermore, the time used for replication between the two strands varies and may lead to asymmetric mutational pressure between leading and lagging strand.
- The second school of thought describes the mechanism of GC and AT skew as resulting from differential selective pressure between the leading and lagging strands.
- This happens at all the sites of the lagging strand, but it does not happen at the end where the last RNA primer is attached.
- During DNA replication of circular bacterial genomes, multiple proteins are involved in synthesizing the leading strand, and the Okazaki fragments on the lagging strand.
- On the lagging strand " template ", a primase " reads " the template DNA and initiates synthesis of a short complementary RNA primer.
- Priming enzymes, ( which are DNA-dependent RNA polymerases ), solve this problem by creating an RNA primer on the leading and lagging strands.
- Then, DNA ligase I binds to the PCNA, which is clamped to the nicks of the lagging strand, and catalyzes the formation of phosphodiester bonds.
- The preferred DNA substrate mimics an arrested DNA replication fork with unreplicated lagging strand, structurally identical to a product of recombinational repair of a stalled replication fork.
- There are two problems after leading and lagging strand synthesis : RNA remains in the duplex and there are nicks between each Okazaki fragment in the lagging duplex.
- Due to the fact that an RNA primer is required for initiation of DNA synthesis, the lagging strand is at a disadvantage in replicating the entire chromosome.