hemophilia b वाक्य

उदाहरण वाक्य

1. A gene therapy treatment for hemophilia B might be of great benefit, he said, and would need to be weighed against the risks, including that of inadvertently modifying the human germ line.
2. The trial, conducted by Avigen of Alameda, Calif ., is designed to insert a corrective gene into the liver of patients with hemophilia B, the less common of two forms of hemophilia.
3. In January 2007, the company announced it would acquire Syntonix Pharmaceuticals for up to $ 120 million, gaining Syntonix's lead product for hemophilia B as well as the technology for developing inhalable treatments.
4. The results, which produced a blood-clotting protein without adverse side effects, were reported in research connected with hemophilia B, which affects about 5, 000 Americans, or 20 percent of all hemophiliacs in America.
5. In 2009 genetic analysis determined specifically that he suffered from hemophilia B . He had to be careful not to injure himself because he lacked factor IX, one of the proteins necessary for blood-clotting.
6. Hemophilia B is a good target for gene therapy because the level of Factor IX in the bloodstream needs to be raised and sustained at only 1 percent of normal for patients to benefit.
7. The trial, conducted by Avigen Inc . of Alameda, Calif ., is designed to insert a corrective gene into the liver of patients with hemophilia B, the less common of two forms of hemophilia.
8. Calcium-binding EGF-like domains ( cbEGF-like domains ) play a seminal role in diseases such as the Marfan syndrome or the X-chromosome linked hemorrhagic disorder hemophilia B and are among the most abundant extracellular calcium-binding domains.
9. But Nagle said hemophilia B is so rare _ only 150 cases are diagnosed annually _ that seven subjects are probably representative of those in the general population who suffer from this rare bleeding disorder.
10. The cause of hemophilia B is decreased activity or deficiency of blood coagulation factor IX . Point mutations resulting in decreased affinity of factor IX to calcium are thought to be implicated in this bleeding disorder.