phosphaturia वाक्य

If there is inappropriately high urine phosphate ( phosphaturia ) in the setting of low serum phosphate ( hypophosphatemia ), there should be a high suspicion for tumor-induced osteomalacia.
The conversion of 25 ( OH ) virtamin D to 1, 25 ( OH ) 2 vitamin D is impaired, reducing intestinal calcium absorption and increasing PTH . The kidney fails to respond adequately to PTH, which normally promotes phosphaturia and calcium reabsorption, or to FGF-23, which also enhances phosphate excretion.
The distal intercalated cells function normally, so the acidemia is less severe than dRTA and the urine can acidify to a pH of less than 5.3 . pRTA also has several causes, and may occasionally be present as a solitary defect, but is usually associated with a more generalised dysfunction of the proximal tubular cells called Fanconi syndrome where there is also phosphaturia, glycosuria, aminoaciduria, uricosuria and tubular proteinuria.